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Human B7-H3/CD276 Protein

Specification

Quota

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Catalog# HA210268

Human B7-H3/CD276 Protein

Product Information

Product name

Human B7-H3/CD276 Protein

Catalog No.

HA210268

Predicted molecular mass

The protein has a predicted MW of 24.7 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.

Protein construction description

Recombinant Human B7-H3/CD276 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Leu29-Pro245.

Accession

Q5ZPR3-2

Source

HEK293

Purity

> 95% as determined by Tris-Bis PAGE

Endotoxin

Less than 1EU per μg by the LAL method.

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Species

Human

Background

B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction.

Usage guide

Storage

-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Reconstitution

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

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