Human NRG1, Tag Free Protein

Quota

Contact Us

Email: [email protected]

Phone: 0571-88062880

Find Local Distributors

Catalog# HA210772

Human NRG1, Tag Free Protein

This product has been cited in peer reviewed publications, see list HERE

Product Information

Product name

Human NRG1, Tag Free Protein

Catalog No.

HA210772

Predicted molecular mass

25.2 kD

Protein construction description

A DNA sequence encoding the human NRG1 protein (Q02297-6) (Ser 20-Lys 246) was expressed with tag free.

Accession

Q02297-6

Protein construction

NRG1 (20-246)

Source

HEK293

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1.

Usage guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

Citation

Filter:

NRG1-ErbB4 signaling in the cerebrospinal fluid-contacting nucleus regulates thermal pain in mice

Author: Yuhan Ding,et al

PMID: 39733821
Journal: Neuroscience
- Application: WB
- Reactivity: Mouse
- Publish date: 2024 Dec
- Citation

Human NRG1, Tag Free Protein

Contact Us

Product Information

Product name

Catalog No.

Predicted molecular mass

Protein construction description

Accession

Protein construction

Source

Purity

Endotoxin

Formulation

Species

Background

Usage guide

Shipping

Storage

Reconstitution

Citation

Products with the same target and pathway

Human SPR, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human CNTF, N-His Tag, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human Sorcin/SRI, N-Twin Strep, C-His, Flag Tag Protein

Application:

Reactivity: Human

Conjugate:

Human TNF-alpha, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human TNF-alpha, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human Apolipoprotein E/APOE4 (C130R), Tag Free

Application:

Reactivity: Human

Conjugate:

Human Cystatin C, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human MAPK12, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human RAC1, C-Flag Tag Protein

Application:

Reactivity: Human

Conjugate:

Human Caspase-9/CASP9, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human EIF2AK3/PERK, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human TNF RI/TNFRSF1A, Tag Free (ECD) Protein

Application:

Reactivity: Human

Conjugate:

Human DLK1, C-His Tag (ECD) Protein

Application:

Reactivity: Human

Conjugate:

Human C-Reactive Protein/CRP, C-His, Flag Tag

Application:

Reactivity: Human

Conjugate:

Human KIF5B, N-Twin Strep, C-His Tag Protein

Application:

Reactivity: Human