CD38 Recombinant Rabbit Monoclonal Antibody [PSH20-33] - BSA and Azide free
Catalog# HA751749
CD38 Recombinant Rabbit Monoclonal Antibody [PSH20-33] - BSA and Azide free
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WB
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Mouse
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HA724144
含抗保成分
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unconjugated
Overview
Product Name
CD38 Recombinant Rabbit Monoclonal Antibody [PSH20-33] - BSA and Azide free
Antibody Type
Recombinant Rabbit monoclonal Antibody
Species Reactivity
Mouse
Validated Applications
WB
Target Molecular Weight
Predicted band size: 34 kDa
Positive Control
Mouse spleen tissue lysate, Mouse small intestine tissue lysate.
Conjugation
unconjugated
Clone Number
PSH20-33
Product Features
Form
Liquid
Concentration
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4).
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
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WB
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1:5,000
Target
Function
CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lymphocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabolites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.
Background References
1. Yang Q et al. NADase CD38 is a key determinant of ovarian aging. Nat Aging. 2024 Jan
2. Yu S et al. CD38-Targeting Peptide Vaccine Ameliorates Aging-Associated Phenotypes in Mice. Aging Cell. 2025 Sep
Subcellular Location
Cell surface, Membrane.
UNIPROT
Synonyms
Acute lymphoblastic leukemia cells antigen CD38 antibody
ADP ribosyl cyclase 1 antibody
ADP ribosyl cyclase antibody
ADP ribosyl cyclase/cyclic ADP-ribose hydrolase antibody
ADP-ribosyl cyclase 1 antibody
ADPRC 1 antibody
ADPRC1 antibody
cADPr hydrolase 1 antibody
CD 38 antibody
CD38 antibody
ExpandImages
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Western blot analysis of CD38 on different lysates with Rabbit anti-CD38 antibody (HA751749) at 1/5,000 dilution.
Lane 1: Mouse spleen tissue lysate
Lane 2: Mouse small intestine tissue lysate
Lysates/proteins at 40 µg/Lane.
Predicted band size: 34 kDa
Observed band size: 45 kDa
Exposure time: 10 seconds; ECL: K1801;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA751749) at 1/5,000 dilution was used in primary antibody dilution (K1803) at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"