Human IL-19, Tag Free Protein

Specification

20μg

50μg

100μg

Quota

Contact Us

BIO-STATION LIMITED

Contact: Sanry CHEN

Email: info@bio-station.net

Phone: 852-35650223

Find Local Distributors

Catalog# HA211269

Human IL-19, Tag Free Protein

Product Information

Product name

Human IL-19, Tag Free Protein

Catalog No.

HA211269

Predicted molecular mass

18.6 kD

Protein construction description

A DNA sequence encoding the human IL-19 protein (Q9UHD0-1) (Leu 25-Ala 177) was expressed with tag free.

Accession

Q9UHD0-1

Protein construction

IL-19 (25-177)

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. Cytokine that functions as an anti-inflammatory and proangiogenic factor. Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13. Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (By similarity). Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB. In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3.

Usage guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

Human IL-19, Tag Free Protein

Specification

Contact Us

BIO-STATION LIMITED

Product Information

Product name

Catalog No.

Predicted molecular mass

Protein construction description

Accession

Protein construction

Source

Bio Activity

Purity

Endotoxin

Formulation

Species

Background

Usage guide

Shipping

Storage

Reconstitution

Products with the same target and pathway

Human TRAIL/TNFSF10, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human IL-9, C-Flag Tag Protein

Application:

Reactivity: Human

Conjugate:

Human IL-25/IL-17E, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human IFN-gamma, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human IL-21, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human IL-5, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human IL-17A, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human IL-6, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human TNFSF11/RANKL/CD254, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human IL-7, C-His, Flag Tag Protein

Application:

Reactivity: Human

Conjugate:

Human IL-33, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human M-CSF/CSF1 (33-255), C His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human IL-17F, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human IL-18, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human LTA, Tag Free Protein