Tyrosine Hydroxylase Rabbit Polyclonal Antibody

Function

The enzyme tyrosine hydroxylase (TH), also designated tyrosine 3-monooxygenase (TY3H), catalyzes the conversion of tyrosine to L-dopa, which is the rate limiting step in the biosynthesis of catecholamines such as dopamine, adrenalin and noradrenalin. TH is thought to play a role in the pathogenesis of Parkinson's disease, which is associated with reduced dopamine levels. Two transcription factor binding sites in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been implicated in the complex regulation of the TH gene. TH is also known to be upregulated by the glia maturation factor (GMF), a Cdc 10/SWI6 motif-containing protein called V-1, and a variety of additional compounds.

Background References

1. Ho TJ et al. Effects of Electroacupuncture on Methamphetamine-Induced Behavioral Changes in Mice. Evid Based Complement Alternat Med 2017:5642708 (2017).

2. Bourdenx M et al. Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases. Autophagy 12:472-83 (2016).

Sequence Similarity

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Tissue Specificity

Mainly expressed in the brain and adrenal glands.

Subcellular Location

Cytoplasm. Nucleus.

UNIPROT

SwissProt: P07101 Human

SwissProt: P24529 Mouse

SwissProt: P04177 Rat

Synonyms