p16INK4a Recombinant Rabbit Monoclonal Antibody [SU0702]

Function

p16 (also known as p16INK4a, cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S phase, thereby acting as a tumor suppressor. It is encoded by the CDKN2A gene. A deletion (the omission of a part of the DNA sequence during replication) in this gene can result in insufficient or non-functional p16, accelerating the cell cycle and resulting in many types of cancer. p16 can be used as a biomarker to improve the histological diagnostic accuracy of grade 3 cervical intraepithelial neoplasia (CIN). p16 is also implicated in the prevention of melanoma, oropharyngeal squamous cell carcinoma, cervical cancer, vulvar cancer and esophageal cancer.

Background References

1. Idriss MH et al. Orthokeratotic Bowen disease: a histopathologic, immunohistochemical and molecular study. J Cutan Pathol 43:24-31 (2016).

2. Liang L et al. Assessment of the Utility of PAX8 Immunohistochemical Stain in Diagnosing Endocervical Glandular Lesions. Arch Pathol Lab Med 140:148-52 (2016).

Sequence Similarity

Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.

Tissue Specificity

Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.

Post-translational Modification

Phosphorylation seems to increase interaction with CDK4.

Subcellular Location

Cytoplasm, Nucleus.

UNIPROT

SwissProt: P42771 Human

Synonyms