Human IL1RL1/DER4/ST2, C-hFc, His (ECD) Protein

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Catalog# HA210589

Human IL1RL1/DER4/ST2, C-hFc, His (ECD) Protein

Product Information

Product name

Human IL1RL1/DER4/ST2, C-hFc, His (ECD) Protein

Catalog No.

HA210589

Predicted molecular mass

62.3 kD

Protein construction description

A DNA sequence encoding the human IL1RL1/DER4/ST2 protein (Q01638) (Lys 19-Ser 328) was expressed with both hFc, his tag at the C-terminus.

Accession

Q01638

Protein construction

IL1RL1/DER4/ST2 (19-328) hFc His

Source

HEK293

Bio Activity

Testing in progress.

Purity

>90% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages.

Usage guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.